(CBS) Each year, people spend more than $40 billion on products designed to
help them slim down. None of them seem to be working very well.
Now along comes hoodia. Never heard of it? Soon it'll be tripping off your
tongue, because hoodia is a natural substance that literally takes your appetite
It's very different from diet stimulants like Ephedra and Phenfen that are now
banned because of dangerous side effects. Hoodia doesn't stimulate at all.
Scientists say it fools the brain by making you think you’re full, even if
you've eaten just a morsel. Correspondent Lesley Stahl reports.
"Hoodia, a plant that tricks the brain by making the stomach feel full, has been
in the diet of South Africa's Bushmen for thousands of years."
Because the only place in the world where hoodia grows wild is in the Kalahari
Desert of South Africa.
Nigel Crawhall, a linguist and interpreter, hired an experienced tracker named
Toppies Kruiper, a local aboriginal Bushman, to help find it. The Bushmen were
featured in the movie “The Gods Must Be Crazy.”
Kruiper led 60 Minutes crews out into the desert. Stahl asked him if he ate
hoodia. "I really like to eat them when the new rains have come," says Kruiper,
speaking through the interpreter. "Then they're really quite delicious."
When we located the plant, Kruiper cut off a stalk that looked like a small
spiky pickle, and removed the sharp spines. In the interest of science, Stahl
ate it. She described the taste as "a little cucumbery in texture, but not bad."
So how did it work? Stahl says she had no after effects – no funny taste in her
mouth, no queasy stomach, and no racing heart. She also wasn't hungry all day,
even when she would normally have a pang around mealtime. And, she also had no
desire to eat or drink the entire day. "I'd have to say it did work," says
Although the West is just discovering hoodia, the Bushmen of the Kalahari have
been eating it for a very long time. After all, they have been living off the
land in southern Africa for more than 100,000 years.
Some of the Bushmen, like Anna Swartz, still live in old traditional huts, and
cook so-called Bush food gathered from the desert the old-fashioned way.
The first scientific investigation of the plant was conducted at South Africa’s
national laboratory. Because Bushmen were known to eat hoodia, it was included
in a study of indigenous foods.
"What they found was when they fed it to animals, the animals ate it and lost
weight," says Dr. Richard Dixey, who heads an English pharmaceutical company
called Phytopharm that is trying to develop weight-loss products based on hoodia.
Was hoodia's potential application as an appetite suppressant immediately
"No, it took them a long time. In fact, the original research was done in the
mid 1960s," says Dixey.
It took the South African national laboratory 30 years to isolate and identify
the specific appetite-suppressing ingredient in hoodia. When they found it, they
applied for a patent and licensed it to Phytopharm.
Phytopharm has spent more than $20 million so far on research, including
clinical trials with obese volunteers that have yielded promising results.
Subjects given hoodia ended up eating about 1,000 calories a day less than those
in the control group. To put that in perspective, the average American man
consumes about 2,600 calories a day; a woman about 1,900.
"If you take this compound every day, your wish to eat goes down. And we've seen
that very, very dramatically," says Dixey.
But why do you need a patent for a plant? "The patent is on the application of
the plant as a weight-loss material. And, of course, the active compounds within
the plant. It’s not on the plant itself," says Dixey.
So no one else can use hoodia for weight loss? "As a weight-management product
without infringing the patent, that’s correct," says Dixey.
But what does that say about all these weight-loss products that claim to have
hoodia in it? Trimspa says its X32 pills contain 75 mg of hoodia. The company is
pushing its product with an ad campaign featuring Anna Nicole Smith, even though
the FDA has notified Trimspa that it hasn’t demonstrated that the product is
Some companies have even used the results of Phytopharm’s clinical tests to
market their products.
"This is just straightforward theft. That’s what it is. People are stealing
data, which they haven’t done, they’ve got no proper understanding of, and
sticking on the bottle," says Dixey. "When we have assayed these materials, they
contain between 0.1 and 0.01 percent of the active ingredient claimed. But they
use the term hoodia on the bottle, of course, so they -- does nothing at all."
But Dixey isn’t the only one who’s felt ripped off. The Bushmen first heard the
news about the patent when Phytopharm put out a press release. Roger Chennells,
a lawyer in South Africa who represents the Bushmen, who are also called “the
San,” was appalled.
"The San did not even know about it," says Chennells. "They had given the
information that led directly toward the patent."
The taking of traditional knowledge without compensation is called “bio-piracy.”
"You have said, and I'm going to quote you, 'that the San felt as if someone had
stolen the family silver,'" says Stahl to Chennells. "So what did you do?"
"I wouldn't want to go into some of the details as to what kind of letters were
written or what kind of threats were made," says Chennells. "We engaged them.
They had done something wrong, and we wanted them to acknowledge it."
Chennells was determined to help the Bushmen who, he says, have been exploited
for centuries. First they were pushed aside by black tribes. Then, when white
colonists arrived, they were nearly annihilated.
"About the turn of the century, there were still hunting parties in Namibia and
in South Africa that allowed farmers to go and kill Bushmen," says Chennells.
"It's well documented."
The Bushmen are still stigmatized in South Africa, and plagued with high
unemployment, little education, and lots of alcoholism. And now, it seemed they
were about to be cut out of a potential windfall from hoodia. So Chennells
threatened to sue the national lab on their behalf.
"We knew that if it was successful, many, many millions of dollars would be
coming towards the San," says Chennells. "Many, many millions. They've talked
about the market being hundreds and hundreds of millions in America."
In the end, a settlement was reached. The Bushmen will get a percentage of the
profits -- if there are profits. But that’s a big if.
The future of hoodia is not yet a sure thing. The project hit a major snag last
year. Pharmaceutical giant Pfizer, which had teamed up with Phytopharm, and
funded much of the research, dropped out when making a pill out of the active
ingredient seemed beyond reach.
Dixey says it can be made synthetically: "We've made milligrams of it. But it's
very expensive. It's not possible to make it synthetically in what’s called a
scaleable process. So we couldn’t make a metric ton of it or something that is
the sort of quantity you’d need to actually start doing something about obesity
in thousands of people."
Phytopharm decided to market hoodia in its natural form, in diet shakes and
bars. That meant it needed the hoodia plant itself.
But given the obesity epidemic in the United States, it became obvious that what
was needed was a lot of hoodia - much more than was growing in the wild in the
Kalahari. And so they came here.
60 Minutes visited one of Phytopharm’s hoodia plantations in South Africa.
They’ll need a lot of these plantations to meet the expected demand.
Agronomist Simon MacWilliam has a tall order: grow a billion portions a year of
hoodia, within just a couple of years. He admitted that starting up the
plantation has been quite a challenge.
"The problem is we’re dealing with a novel crop. It’s a plant we’ve taken out of
the wild and we’re starting to grow it,' says MacWilliam. "So we have no
experience. So it’s different— diseases and pests which we have to deal with."
How confident are they that they will be able to grow enough? "We're very
confident of that," he says. "We've got an expansion program which is going to
be 100s of acres. And we'll be able – ready to meet the demand.
This could be huge, given the obesity epidemic. Phytopharm says it’s about to
announce marketing plans that will have meal-replacement hoodia products on
supermarket shelves by 2008.
MacWilliam says these products are a slightly different species from the hoodia
Stahl tasted in the Kalahari Desert. "It's actually a lot more bitter than the
plant that you tasted," says MacWilliam.
The advantage is this species of hoodia will grow a lot faster. But more bitter?
How bad could it be? Stahl decided to find out. "Not good," she says.
Phytopharm says that when its product gets to market, it will be certified safe
and effective. They also promise that it’ll taste good.
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